(Source: HighWire Press) - Amyloid-beta has long been implicated in the development of Alzheimer's. A majority of research into this disease has focused on the clumping of amyloid-beta in the brain, however, recent studies have revealed amyloid-beta appearing inside brain cells, suggesting a different mechanism of neurodegenerative pathology. In this study, Case Western Reserve University scientists note that both mechanisms, extracellular and intracellular amyloid-beta deposits, induce neuronal toxicity.
Little is known about the underlying causes of amyloid-beta neurodegenerative decline. However, the researchers point out that brain cells rely heavily on mitochondria (components of cells containing genetic material) and suspect that they may be an important target of amyloid-beta.
Got to full story: stanford.edu
